AngioDynamics NanoKnife is the first surgical ablation system based on Irreversible Electroporation (IRE) technology and represents the next generation in focal ablative therapy.

IRE is a technique using non-thermal energy to create permanent nanopores in the cell membrane to disrupt cellular homeostasis.

The disruption of cellular homeostasis initiates an apoptotic-like effect, which leads to permanent cell death. Unlike thermal modalities, zones of IRE ablation are not deformed or decreased by proximity to blood vessels.

The NanoKnife System reimagines localised therapy through its unique mechanism of action, improving precision, expanding versatility, and increasing preservation.

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Key Features

• Harnesses the power of Irreversible Electroporation (IRE) to effectively destroy targeted cells without the use of thermal energy.
• Delivers high-voltage pulses to create permanent nanopores within the cell membrane. This stimulus induces an apoptotic-like cellular death in the targeted tissue, resulting in a complete ablation.
• Electrodes can be deployed in multiple configurations providing precise and customisable ablation zones.
• Sharp demarcation of IRE-ablated zone is well-visualised immediately during the procedure using real-time ultrasound imaging.
• Precision Empowered.
• The NanoKnife System gives the physician the ability to sculpt and control the ablation zone through a variety of electrode configurations.
• IRE effectively destroys the targeted tissue and gives you precise treatment margins resulting in confident treatment coverage for your procedure.
• Preservation Redefined.
• The procedure spares vital structures by retaining the structural integrity of the targeted tissue.
• The delivery of non-thermal energy allows for the preservation of the extra-cellular matrix, facilitating post-ablation, histological and functional tissue regeneration.
• Versatility Perfected.
• Multiple electrode configurations, coupled with a unique mechanism of action, allow the device to be used in all segments of an organ to optimize treatment delivery.
• Electrodes can be confidently placed near vital structures, maximising your ability to personalize treatment to your patient’s anatomy.