Introducing AngioDynamics’ NanoKnife 3.0 System

AngioDynamics are a leading provider of minimally invasive medical devices in the field of interventional oncology, surgery, vascular access and peripheral vascular disease. With a global reach and mission, AngioDynamics seeks to improve patient outcomes with the development of new disruptive and differentiated technologies. 

What is the NanoKnife 3.0 System indicated for? 

Harnessing the power and precision of next-generation Irreversible Electroporation (IRE) technology, AngioDynamics’ NanoKnife 3.0 System effectively targets and destroys cancerous and malignant cells—without the use of thermal energy. Changing the landscape of oncology treatments, the NanoKnife 3.0 System empowers providers with the ability to sculpt and control the IRE ablation zone to target diseased tissues with precise margins. By utilising non-thermal energy, the NanoKnife 3.0 System allows vital structures and the integrity of tissues to be spared, effectively facilitating post-ablation, histological and functional tissue regeneration.  

How does the technology work? 

The NanoKnife 3.0 System utilises IRE to effectively destroy diseased tissue without the need for thermal energy. Two or more minimally invasive needle electrodes are positioned in or around the diseased tissue using real-time ultrasound guidance or CT. High-voltage pulses are delivered between the electrodes and can be competently delivered in all segments of an organ to create irreversible nanopores within the cell membrane. This stimulus induces an apoptotic-like cellular death, resulting in the complete ablation of tissue within the electrode configuration. The body responds to the apoptotic-like cell death by initiating the removal of cellular debris.  

Delivery of non-thermal energy ensures the conservation of the extra-cellular matrix. The unique mechanism of action enables the preservation of vital structures inside the ablation zone, facilitating the histological and functional regeneration of tissue following treatment. As a result, the NanoKnife 3.0 System reimagines localised ablative therapy to deliver treatments with improved margins precision and increased preservation. 

To learn more about the AngioDynamics NanoKnife 3.0 System, contact the Getz Healthcare Team today.